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1977•Chemical and Pharmaceutical BulletinOpen access

Copper in cadmium-exposed rat kidney metallothionein.

Kazuo Suzuki, Kentaro Kubota, Shinji Takenaka

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Abstract

In vitro affinity of cupric ion to metallothionein was found to be stronger than cadmium and zinc ions. The result suggested the passive incorporation of copper into the metallothionein and the possibility of demasking of the masked cadmium toxicity as metallothionein. Copper contents of cadmium-exposed rat kidney metallothionein were analyzed along with cadmium and zinc. The copper in kidney metallothionein was always one of major metals along with zinc and cadmium. On the other hand, the copper in cadmium-exposed liver metallothionein was a minor metal.

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In vitro affinity of cupric ion to metallothionein was found to be stronger than cadmium and zinc ions. The result suggested the passive incorporation of copper into the metallothionein and the possibility of demasking of the masked cadmium toxicity as metallothionein. Copper contents of cadmium-exposed rat kidney metallothionein were analyzed along with cadmium and zinc. The copper in kidney metallothionein was always one of major metals along with zinc and cadmium. On the other hand, the copper in cadmium-exposed liver metallothionein was a minor metal.

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Available abstract

In vitro affinity of cupric ion to metallothionein was found to be stronger than cadmium and zinc ions. The result suggested the passive incorporation of copper into the metallothionein and the possibility of demasking of the masked cadmium toxicity as metallothionein. Copper contents of cadmium-exposed rat kidney metallothionein were analyzed along with cadmium and zinc. The copper in kidney metallothionein was always one of major metals along with zinc and cadmium. On the other hand, the copper in cadmium-exposed liver metallothionein was a minor metal.

Key concepts: Metallothionein, Cadmium, Zinc, Chemistry, Copper, Metal, Toxicity, Kidney

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