Drug-and-food Interraction

It was reported that in a clinical study prothrombin time in patients under anticoagulant therapy changed after intake of green vegetables. The relation between anticoagulant warfarin potassium, vitamin K and prothrombin time was investigated. Vitamin K2 was administered intravenously to the rabbits with hypoprothrombinemia caused by the oral administration of warfarin potassium. As a result, remarkable suppression of prolongation of prothrombin time was shown. When a spinach extract was given to these rabbits, the same effect was observed. Therefore, it was considered that prothrombin time in patients taking anticoagulants was influenced by the intake of green vegetables rich in vitamin K such as spinach.