2014•Nihon Kessho GakkaishiOpen access

Integrated Structural Biology in Combination with SAXS Analysis for Biological Macromolecules

Takashi Oda, Hiroshi Hashimoto

Abstract

Small angle X-ray scattering (SAXS) analysis is a facile and useful method to determine structures of biological macromolecules in solution. Although SAXS analysis generally provides significant information of molecular shape at low resolution, in combination with other biophysical techniques such as X-ray crystallography, SAXS analysis exhibits tremendous power for structural studies of biological macromolecules. In this review, we described our recent studies of SAXS analysis for biological macromolecules (BioSAXS) and future perspective for integrated structural biology using BioSAXS.

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Key concepts: Small-angle X-ray scattering, Macromolecule, Materials science, Scattering, Nanotechnology, Chemistry, Physics, Biochemistry