1941•Experimental Biology and MedicineRequires access

Effect of Sulfonamide Compounds upon Growth of Staphylococci in Presence and Absence of p-Aminobenzoic Acid.

Wesley W. Spink, J. Jermsta

Abstract

ConclusionsA synthetic, chemically-defined medium has proved satisfactory for the study of the bacteriostatic effect of the sulfonamide compounds upon staphylococci. Sulfathiazole and sulfadiazine have a definitely greater inhibitory effect upon growth compared to sulfapyridine and sulfanilamide, with sulfathiazole superior to sulfadiazine. While p-aminobenzoic acid inhibits this bacteriostatic action of all the compounds studied, the greater the effect of a compound upon growth of Staphylococci, the less inhibitory is p-aminobenzoic acid against this action of the compound.

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Key concepts: P-Aminobenzoic acid, Sulfonamide, Sulfanilamide, Aminobenzoic acid, Chemistry, Microbiology, Food science, Biochemistry