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Effect of Glyceryl Trinitrate on Pulmonary Vasculature of Anesthetized Dogs.

Alan L. Pinkerson, P. A. Kot, Donald M. Knowlan

Open publisher page 14 citations

Abstract

SummaryThe effect of GTN on the pulmonary vasculature was tested in animals with an intact circulation, with a mechanical pump substituted for the left ventricle and with the pump by-passing the right ventricle. The results of the experiments indicate that in anesthetized dogs the direct effect of GTN in the pulmonary circuit is to decrease pulmonary vascular resistance. The observed increase in pulmonary artery pressure in intact dogs following the injection of GTN is due to increased pulmonary blood flow.

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What this paper is about

SummaryThe effect of GTN on the pulmonary vasculature was tested in animals with an intact circulation, with a mechanical pump substituted for the left ventricle and with the pump by-passing the right ventricle. The results of the experiments indicate that in anesthetized dogs the direct effect of GTN in the pulmonary circuit is to decrease pulmonary vascular resistance. The observed increase in pulmonary artery pressure in intact dogs following the injection of GTN is due to increased pulmonary blood flow.

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OpenAlex reports 14 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

SummaryThe effect of GTN on the pulmonary vasculature was tested in animals with an intact circulation, with a mechanical pump substituted for the left ventricle and with the pump by-passing the right ventricle. The results of the experiments indicate that in anesthetized dogs the direct effect of GTN in the pulmonary circuit is to decrease pulmonary vascular resistance. The observed increase in pulmonary artery pressure in intact dogs following the injection of GTN is due to increased pulmonary blood flow.

Key concepts: Medicine, Pulmonary vasculature, Cardiology, Pulmonary artery, Anesthesia, Nitroglycerin (drug), Internal medicine

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Effect of Glyceryl Trinitrate on Pulmonary Vasculature of Anesthetized Dogs. — Research Paper | ScholarLens