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2016•Pain ManagementRequires access

Modulation of Serum BDNF Levels in Postherpetic Neuralgia Following Pulsed Radiofrequency of Intercostal Nerve and Pregabalin

Ashok Kumar Saxena, Kavitha Lakshman, Tusha Sharma, Neha Gupta, Basu Dev Banerjee, Archana Singal

Open publisher page 30 citations

Abstract

AIM: To study the modulation of serum BDNF levels following integrated multimodal intervention in postherpetic neuralgia (PHN). MATERIALS & METHODS: A randomized, double-blind controlled study was undertaken among patients of thoracic PHN where 30 patients received pregabalin with pulsed radiofrequency and 30 controls received pregabalin with sham treatment. RESULTS: Pain intensity (visual analog scale) was reduced earlier in intervention group (15.3 ± 5.7 at the fourth week) compared with control group (16.3 ± 6.6 at the eighth week). Serum BDNF level increased with time in both the groups with overall increase more pronounced in intervention group. CONCLUSION: Integrated multimodal therapy using minimally invasive pulsed radiofrequency and pregabalin in PHN was effective in early pain reduction with elevated serum BDNF levels.

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What this paper is about

AIM: To study the modulation of serum BDNF levels following integrated multimodal intervention in postherpetic neuralgia (PHN). MATERIALS & METHODS: A randomized, double-blind controlled study was undertaken among patients of thoracic PHN where 30 patients received pregabalin with pulsed radiofrequency and 30 controls received pregabalin with sham treatment. RESULTS: Pain intensity (visual analog scale) was reduced earlier in intervention group (15.3 ± 5.7 at the fourth week) compared with control group (16.3 ± 6.6 at the eighth week). Serum BDNF level increased with time in both the groups with overall increase more pronounced in intervention group. CONCLUSION: Integrated multimodal therapy using minimally invasive pulsed radiofrequency and pregabalin in PHN was effective in early pain reduction with elevated serum BDNF levels.

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Available abstract

AIM: To study the modulation of serum BDNF levels following integrated multimodal intervention in postherpetic neuralgia (PHN). MATERIALS & METHODS: A randomized, double-blind controlled study was undertaken among patients of thoracic PHN where 30 patients received pregabalin with pulsed radiofrequency and 30 controls received pregabalin with sham treatment. RESULTS: Pain intensity (visual analog scale) was reduced earlier in intervention group (15.3 ± 5.7 at the fourth week) compared with control group (16.3 ± 6.6 at the eighth week). Serum BDNF level increased with time in both the groups with overall increase more pronounced in intervention group. CONCLUSION: Integrated multimodal therapy using minimally invasive pulsed radiofrequency and pregabalin in PHN was effective in early pain reduction with elevated serum BDNF levels.

Key concepts: Postherpetic neuralgia, Medicine, Intercostal nerves, Pulsed radiofrequency, Pregabalin, Anesthesia, Neuralgia, Neuropathic pain

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Modulation of Serum BDNF Levels in Postherpetic Neuralgia Following Pulsed Radiofrequency of Intercostal Nerve and Pregabalin — Research Paper | ScholarLens