1978•Experimental Biology and MedicineRequires access

Granulocyte Colony Formation in Chronic Granulocytic Leukemia during Stable, Accelerated and Blastic Disease

C. A. Rhodes, William Allen Robinson, Maureen A. Entringer

Abstract

The number of granulocyte colony forming cells (CFU-C) has been determined in the peripheral blood and bone marrow of patients with chronic granulocytic leukemia (CGL) during the stable, accelerated and blastic phases of the disease. These studies have corroborated previous work indicating that blood CFU-C numbers are high during the stable phase of CGL. In the accelerated and blast phases of CGL, CFU-C numbers in the peripheral blood and bone marrow may be decreased, normal or increased, but are not consistently low. Changes in CFU-C numbers could not be correlated with clinical patterns of CGL, or eventual outcome of the disease.

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Key concepts: Chronic granulocytic leukemia, Bone marrow, Granulocyte, Peripheral blood, Precursor cell, Leukemia, Immunology, Biology