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Fabrication of porous collagen scaffold for cardiovascular engineering

Sin Nee Song

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Abstract

Freeze-drying technique was employed to fabricate a porous collagen scaffold to explore its application in the tissue-engineering of cardiovascular system. The effect of thermal conductivity of mold materials and freezing kinetics on the pore structure of the scaffold was investigated. The influence of dehydrothermal (DHT) process, 1 -ethyl-3-(3-dimethyl aminopropyl)carbodiimide / N-hydroxysuccinimide (EDC/NHS) and glutaraldehyde (GA) cross-linking on the mechanical property was also studied.

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What this paper is about

Freeze-drying technique was employed to fabricate a porous collagen scaffold to explore its application in the tissue-engineering of cardiovascular system. The effect of thermal conductivity of mold materials and freezing kinetics on the pore structure of the scaffold was investigated. The influence of dehydrothermal (DHT) process, 1 -ethyl-3-(3-dimethyl aminopropyl)carbodiimide / N-hydroxysuccinimide (EDC/NHS) and glutaraldehyde (GA) cross-linking on the mechanical property was also studied.

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Available abstract

Freeze-drying technique was employed to fabricate a porous collagen scaffold to explore its application in the tissue-engineering of cardiovascular system. The effect of thermal conductivity of mold materials and freezing kinetics on the pore structure of the scaffold was investigated. The influence of dehydrothermal (DHT) process, 1 -ethyl-3-(3-dimethyl aminopropyl)carbodiimide / N-hydroxysuccinimide (EDC/NHS) and glutaraldehyde (GA) cross-linking on the mechanical property was also studied.

Key concepts: Scaffold, Fabrication, Tissue engineering, Porosity, Nanotechnology, Materials science, Engineering, Biomedical engineering

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