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Ranolazine and Dronedarone in Combination Show Synergistic Effects on AF Suppression

Nathan Frank Glynn Parry, Peter R. Kowey

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Abstract

This article presents results from the Phase 2 Study to Evaluate the Effect of Ranolazine and Dronedarone When Given Alone and in Combination in Patients With Paroxysmal Atrial Fibrillation trial [HARMONY; NCT01522651]. This randomized, double-blind, placebo-controlled trial demonstrated that a combination of ranolazine and low-dose dronedarone reduced the burden of paroxysmal atrial fibrillation when compared with either drug alone.

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What this paper is about

This article presents results from the Phase 2 Study to Evaluate the Effect of Ranolazine and Dronedarone When Given Alone and in Combination in Patients With Paroxysmal Atrial Fibrillation trial [HARMONY; NCT01522651]. This randomized, double-blind, placebo-controlled trial demonstrated that a combination of ranolazine and low-dose dronedarone reduced the burden of paroxysmal atrial fibrillation when compared with either drug alone.

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Available abstract

This article presents results from the Phase 2 Study to Evaluate the Effect of Ranolazine and Dronedarone When Given Alone and in Combination in Patients With Paroxysmal Atrial Fibrillation trial [HARMONY; NCT01522651]. This randomized, double-blind, placebo-controlled trial demonstrated that a combination of ranolazine and low-dose dronedarone reduced the burden of paroxysmal atrial fibrillation when compared with either drug alone.

Key concepts: Ranolazine, Dronedarone, Atrial fibrillation, Medicine, Cardiology, Placebo, Internal medicine, Amiodarone

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Ranolazine and Dronedarone in Combination Show Synergistic Effects on AF Suppression — Research Paper | ScholarLens