Glucose Intolerance Mediated by Ghrelin through the Suppression of Insulin Secretion in Healthy Iraqi Children

Background:Ghrelin, identified as an endogenous ligand for the growth hormone secretagogue receptor, functions as a somatotrophic and orexigenic signal from the stomach.The secretion of ghrelin increases under conditions of negative energy balance, such as starvation, cachexia, and anorexia nervosa, whereas its expression decreases under conditions of positive energy-balance such as feeding, hyperglycemia, and obesity.In addition to having a powerful effect on the secretion of growth hormone, ghrelin stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis.Thus, it is interesting to note that the stomach may play an important role in not only digestion but also as a pituitary growth hormone release and central feeding regulation.Objective:The orexigenic gut hormone ghrelin and its receptor are present in pancreatic islets.Although ghrelin reduces insulin secretion in rodents, its effect on insulin secretion in humans has not been yet established.The goal of this study was to test the hypothesis that circulating ghrelin suppresses insulin secretion in healthy children.Subjects and methods : ELISA method was used to assay Ghrelin and Insulin .By taken blood sample from 40 obese children, 11 overweight children and 29 normal weight healthy children their age (5-11) years.Results: the mean of Ghrelin concentration was significantly lower in obese and overweight children than in controls ( P < 0.000 ) .The mean of Insulin concentration was significantly higher in obese and overweight children than in controls ( P < 0.007) .Negative correlation between Ghrelin and BMI also negative correlation between Ghrelin and Insulin.Conclusion: This study showed that ghrelin reduces insulin secretion and glucose disappearance in healthy children.This findings raise the possibility that endogenous ghrelin has a role in physiologic insulin secretion, and that it antagonists may improve β-cell function.