1955•Experimental Biology and MedicineRequires access

Electrophysiological Investigation of Chlorisondamine Dimethochloride (EcolidTM) A New Ganglionic Blocking Agent

James Schneider, R. F. Moore

Abstract

Chlorisondamine dimethochloride is a new, very potent and long lasting ganglionic blocking agent. Its ganglionic blocking potency was about twice that of pentapyrrolidinium and hexamethonium, whereas its duration of action exceeded that of hexamethonium several times. Both sympathetic and parasympathetic ganglia were blocked by the drug to a similar extent.

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Available abstract

Key concepts: Hexamethonium, Chlorisondamine, Ganglionic blocker, Blocking (statistics), Electrophysiology, Pharmacology, Potency, Medicine