1958•Experimental Biology and MedicineRequires access

Comparative Susceptibility of Cell Cultures to Vaccinia Virus: Application to the Standardization of Smallpox Vaccine

Ernest C. Cutchins, J. David Warren

Abstract

The infectivity of vaccinia virus in calf lymph for bovine, avian and simian cell cultures has been measured in tissue culture, embryonated eggs and rabbit epithelium. Monkey kidney roller tube or plaque titrations appear most sensitive to this virus and provide a simple and reproducible assay method which should have applications in the potency assay of smallpox vaccines.

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Key concepts: Virology, Vaccinia, Embryonated, Infectivity, Smallpox vaccine, Biology, Virus, Smallpox