Potentiating Effect of EDTA on Antibiotics Resistant Staphylococcus aureus

The widespread use of antibiotics is playing a significant role in the emergence of resistant bacteria.It's a need of time to potentiate antibiotics for their activity.Staphylococcus aureus is one of the bacteria acquiring resistance for most of the antibiotics which is a big deal to tackle Staphylococcus aureus infection.The objective of this study is to potentiate the activity of antibiotics against Staphylococcus aureus isolated from skin swab samples.A total of 50 skin swab samples collected resulted into 102 bacterial pathogens which include 70 Staphylococcus aureus.Disc diffusion method was carried out which resulted into 5 antibiotic resistant Staphylococcus aureus.These resistant strains then tested in combination with antibiotic plus EDTA for the study of antibiotic resistance.Five Staphylococcus aureus strains showed resistance against Teicoplanin, Vancomycin and Methicillin.It was observed that some strains which were resistant to the tested antibiotics were become sensitive for that particular antibiotics in combination with EDTA.Combined effect of EDTA with antibiotic potentiated the effect of EDTA on antibiotic resistant Staphylococcus aureus.