In vivo fluoride uptake and remineralization of demineralized enamel by various fluoride application.

The fluoride uptake and remineralization of partially demineralized enamel after various fluoride applications for 10 days were investigated in vivo. The fluoride applications involved use of MFP dentifrice twice a day; 100ppmF mouthrinse once a day; acidulated phosphate fluoride (APF) applied only once; or no treatment (control). The degree of remineralization was evaluated by mineral vol% using microradiography. The following results were obtained.1) The fluoride uptake from dentifrice and mouthrinse were about 1.2-1.5 and 2-3 times higher than that of the controls, respectively. But statistically significant differences were not found between these three groups. The fluoride uptake from APF treatment was about 14-15 times higher than that of the controls, and statistically significantly higher than the other three groups from the first to the fifth layer.2) The remineralization was evident in all four groups except in one control case. The degree of remineralization in the dentifrice was nearly equal to that in the remineralized controls. Remineralization with the rinse was higher in the first and second layer (about 10-20μm depth) than that with the control and the dentifrice. The degree of remineralization for APF was the highest and the remineralization was evident from the surface to the bottom of the lesion area.