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Change of arachidonic acid metabolism in inflamed rat dental pulp.

Takashi Okiji, Chihiro Kobayashi, Imao Sunada, Ikuo Morita, Sei‐itsu Murota

Abstract

The profile of arachidonic acid metabolism in rat dental pulp was studied with a cell-free system. Conversion of exogenously added radioactive arachidonic acid was measured by using thin-layer chromatography. Normal dental pulp could mainly produce 6-keto-PGF1α and 12- or 15-HETE like lipoxygenase product. When rat dental pulp was experimentally inflamed by applying bacterial lipopolysaccharide, increase of arachidonic acid metabolizing activity was observed. Especially PGE2 producing activity was elevated 9.3-fold compared with that of the normal. It was suggested that arachidonic acid metabolites were involved in the development of pulpal inflammation.

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Key concepts: Arachidonic acid, Arachidonic acid metabolism, Pulp (tooth), Chemistry, Metabolism, Lipoxygenase, Lipopolysaccharide, Biochemistry