1955•Experimental Biology and MedicineRequires access
Pteridines and the Nutrition of the Protozoon Crithidia fasciculata.
Harry P. Broquist, Antonia Albrecht
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Abstract
The Trypanosomid flagellate Crithidia fasciculata was found to have a growth requirement for certain 6-substituted pteridines. The most active compound studied was 2-amino-4-hydroxy-6 (1′, 2′-dihydroxy-propyl) pteridine (“biopterin”) which was isolated from human urine. A requirement for both pteroylglutamic acid and an appropriate pteridine was demonstrated for the organism.