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2014•BMJ Case ReportsOpen access

A distinct imaging phenotype in amyotrophic lateral sclerosis confidently detected on T1 MTC

Antônio José da Rocha, Renato Hoffmann Nunes

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Abstract

A 57-year-old woman presented with a progressing asymmetric (left to right) weakness and wasting that spread in the next 3 months from her lower to upper limbs; she exhibited mild hyper-reflexia in all four limbs. No cognitive or sensory impairment was detected. Cerebrospinal fluid and blood analyses were unremarkable. Electromyography showed pathological signs of denervation and chronic reinnervation with spontaneous activity at rest, consistent with a motor neuron disease. The presence of upper motor neuron (UMN) and lower motor neuron (LMN) signs together in multiple regions, on clinical and …

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A 57-year-old woman presented with a progressing asymmetric (left to right) weakness and wasting that spread in the next 3 months from her lower to upper limbs; she exhibited mild hyper-reflexia in all four limbs. No cognitive or sensory impairment was detected. Cerebrospinal fluid and blood analyses were unremarkable. Electromyography showed pathological signs of denervation and chronic reinnervation with spontaneous activity at rest, consistent with a motor neuron disease. The presence of upper motor neuron (UMN) and lower motor neuron (LMN) signs together in multiple regions, on clinical and …

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Available abstract

A 57-year-old woman presented with a progressing asymmetric (left to right) weakness and wasting that spread in the next 3 months from her lower to upper limbs; she exhibited mild hyper-reflexia in all four limbs. No cognitive or sensory impairment was detected. Cerebrospinal fluid and blood analyses were unremarkable. Electromyography showed pathological signs of denervation and chronic reinnervation with spontaneous activity at rest, consistent with a motor neuron disease. The presence of upper motor neuron (UMN) and lower motor neuron (LMN) signs together in multiple regions, on clinical and …

Key concepts: Amyotrophic lateral sclerosis, Medicine, Lower motor neuron, Upper motor neuron, Motor neuron, Reinnervation, Electromyography, Weakness

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