Serum Levels of Omentin in Pseudoexfoliation Syndrome

PURPOSE: Omentin, a member of the adipocytokines family, is derived from adipose tissue and a lower level of serum omentin is considered as a metabolic risk factor. The aim of the present study is to evaluate the serum levels of omentin in patients with pseudoexfoliation syndrome (PES). MATERIALS AND METHODS: Patients without any systemic or ocular disease other than PES were included in the study. Age-matched and sex-matched healthy volunteers without PES were accepted as a control group. After detailed ophthalmologic examination, blood samples were obtained from a forearm vein. Serum levels of omentin were determined by the method of enzyme-linked immunosorbent assay. RESULTS: The mean age of the PES group (12 females, 12 males, n=24) was 75.2 ± 8.4 years, and the control group (10 females, 10 males, n=20) was 75 ± 6.7 years. There was no difference between the groups in terms of age (P=0.93) and sex (P=0.9). The mean serum levels of omentin in the PES group were 801.5 ± 317.1 ng/mL and in the control group were 1150.1 ± 584.1 ng/mL. The mean serum omentin levels were significantly lower in patients with PES (P=0.016). CONCLUSION: Lower levels of serum omentin in patients with PES compared with healthy subjects may support the theory of systemic nature of the disease.