1965•Chemical and Pharmaceutical BulletinOpen access

Metal Complexes of D-Glucosamine and its Derivatives. III. Determinations of Acid Dissociation Constants of D-Glucosamine and its Three O-Methyl Derivatives

Zenzo Tamura, Motoichi Miyazaki, Takamasa Suzuki

Abstract

The acid dissociation constants of D-glucosamine (I) and its three O-methyl derivatives were determined by titration method. The stability of I was also studied representing these compounds by the improved Fehling method preceding to the pH titration, and I was found to be stable in aqueous solution under experimental conditions. From the analysis of the titration data, I could be verified to behave as a mono basic acid by the comparison of the experimental titration curve with the one theoretically calculated. Finally, the pKa values of these four compounds were calculated.

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Key concepts: Chemistry, Titration, Dissociation constant, Acid dissociation constant, Aqueous solution, Titration curve, Glucosamine, Dissociation (chemistry)