Blastomycosis: Occurrence of Filamentous Formsin Vivo

Filamentous or hyphal forms of Blastomyces dermatitidis have not been observed in vivo . A fresh preparation of sputum from a patient with extensive pulmonary blastomycosis contained hyphal forms. Necropsy disclosed hyphal forms in tissue sections from this patient. A fresh preparation of sputum from a second patient contained similar hyphal forms of Blastomyces dermatitidis . This patient responded to treatment with amphotericin B and is well at the present time. In each case, the possibility of a dual infection was excluded by repeated cultures which grevi Blastomyces dermatitidis only.