1975•Experimental Biology and MedicineRequires access

The Renin and Iso-Renin-Angiotensin Systems in Rats with Experimental Pituitary Tumors

Detlev Ganten, Ursula Ganten, P. Schelling, Rene´ Boucher, Jacques J. Genest

Abstract

Renin, iso-renin, angiotensin I. angiotensin-converting enzyme, and angiotensinases were measured in plasma and in various extrarenal tissues of rats. Despite complete suppression of plasma renin in rats bearing pituitary tumors iso-renin and all other components of the renin-angiotensin system were found to be at or above control concentrations. The results strongly suggest that there is local synthesis of iso-renin in extrarenal tissues.

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Key concepts: Renin–angiotensin system, Endocrinology, Internal medicine, Plasma renin activity, Chemistry, Medicine, Blood pressure