1993•Biological and Pharmaceutical BulletinOpen access

An acute and focal osteopenia model using ovariectomized rats: a rapid detection of the protective effect of salmon calcitonin.

Hiromichi Nakamuta, Minoru Sasaki, Masaki ICHIKAWA, Masao Koida

Abstract

A screening method for anti-osteoporotics using ovariectomized rats was designed using a compact method to monitor the bone density. It was found that ovariectomy (OVX) of Wistar female rats (11 weeks old) induced acute and focal osteopenia within 2 weeks, which responded well to intermittent salmon calcitonin (SCT: 5 and 20 U/kg, s.c., every other day) employed as the standard anti-osteoporotic and injected up to 4 weeks with or without a delay of 2 weeks after OVX.

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Key concepts: Ovariectomized rat, Salmon calcitonin, Osteopenia, Calcitonin, Medicine, Internal medicine, Endocrinology, Osteoporosis