Myocilin and Glaucoma its Risk Factors

Myocilin (OMIM601652) MYOC gene, first revealed as a protein isolated from cultured human Trabecular Meshwork (TM) cells after prolong dexame thasone treatment. Hence given the name TIGR (Trabecular Meshwork Inducible Glucocorticoid Response Protein). The human myocilin gene, a concealed acidic glycoprotein,contains 504 amino acids, positioned at chromosome 1(1q24.3 ‐ 1q25.2), and filled with olfactomedin do main at its C terminus. Myocilin exists in various tissues throughout the eye and many other organs. M utant myocilin cause endoplasmic reticulum pressure in eye angle tissues, including the trabec ular meshwork, damaging the cells inside the meshwork, ultimately leading to structural changes in the outflow pathway, and high intraocular pressure.TM is vital in controlling pressure and mu tations in MYOC.It has been recognized as the cause of juvenile and adult onset of primary open a ngle glaucoma.