2014•Nihon Shoni Arerugi Gakkaishi The Japanese Journal of Pediatric Allergy and Clinical ImmunologyOpen access

Fractional exhaled nitric oxide (FeNO) and exhaled breath condensate (EBC) in the management of asthma in children

Toshio Katsunuma, Kennichi Akashi, Masako Watanabe

Abstract

小児気管支喘息における気道炎症レベルの有力なモニター法として呼気中一酸化窒素（Fractional exhaled nitric oxide；FeNO）分析，呼気凝集液（Exhaled Breath Condensate；以下EBCと略）分析に期待が集まる．近年，ポータブル型FeNO測定機が医療機器として承認され，その使用が容易となった．FeNOは喘息の診断のみならず，重症度判定，治反応性等にも応用可能である．EBCに関しては，過酸化水素等酸化ストレスマーカー，ロイコトリエン等エイコサノイド，サイトカイン等の測定が可能である．臨床所見・呼吸機能にFeNO, EBC等のデータを加味して診療を進めることが最良と考える．

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Key concepts: Exhaled nitric oxide, Exhaled breath condensate, Medicine, Exhalation, Asthma, Nitric oxide, Exhaled air, Internal medicine