ScholarLens Back to search
2000•Drugs of todayRequires access

Sildenafil citrate (Viagra(R))

Gerald B Brock

Open publisher page 34 citations

Abstract

Sildenafil citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type V (PDE V), initially designated as compound 92-480-10 by Pfizer, was studied in the late 1980s as an antianginal. An unexpected side effect of the early clinical investigations was improved erectile function among the men studied. This serendipitous finding has transformed the field of erectile dysfunction therapy (1-3). The novelty of this compound is its oral route of delivery and efficacy across a broad range of etiologies.

About this research paper

What this paper is about

Sildenafil citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type V (PDE V), initially designated as compound 92-480-10 by Pfizer, was studied in the late 1980s as an antianginal. An unexpected side effect of the early clinical investigations was improved erectile function among the men studied. This serendipitous finding has transformed the field of erectile dysfunction therapy (1-3). The novelty of this compound is its oral route of delivery and efficacy across a broad range of etiologies.

Why it matters

OpenAlex reports 34 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Sildenafil citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type V (PDE V), initially designated as compound 92-480-10 by Pfizer, was studied in the late 1980s as an antianginal. An unexpected side effect of the early clinical investigations was improved erectile function among the men studied. This serendipitous finding has transformed the field of erectile dysfunction therapy (1-3). The novelty of this compound is its oral route of delivery and efficacy across a broad range of etiologies.

Key concepts: Sildenafil, Medicine, Cyclic guanosine monophosphate, Erectile dysfunction, cGMP-specific phosphodiesterase type 5, Pharmacology, Erectile function, Phosphodiesterase

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Sildenafil citrate (Viagra(R)) — Research Paper | ScholarLens