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THE COMBINED EFFECT OF X-RAYS AND E 39 ON CELL RESPIRATION
Rick J. Koch, D. Klemm, Joachim Woenckhaus
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Abstract
The separate and corabined effects of x rays and E 39 on respiration in tumor cells and radiosensitive normal cells is discussed. It was found that E 39 causes greater respiratory inhibition in Ehrlich mouse-ascites in vitro, whereas x rays cause greater inhibition in spleen cells. Tumor cells from a retothelial sarcoraa reacted similarly to both E 39 and x rays. In thymus cells no verified difference was found between treated cells and untreated controls. The combination of cystostatic agent and irradiation is by no means more effective. In spleen cells in vivo, the combination of the two is more effective if low radiation doses are used. Radiation is verifiably superior in retothelial sarcoma. Increasing the radiation dose produces a stronger radiation effect, which becomes even clearer after a five day observation period. In the spleen, the effect of the individual components cannot be increased by applying them simultaneously. (auth)