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2014•Technical Reports of the Australian Museum onlineOpen access

Koala retrovirus (KoRV): molecular biology and evolution

Alex D. Greenwood, Alfred L. Roca

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Abstract

The koala retrovirus (KoRV) is in transition between occurring as an exogenous retrovirus spread by infection and becoming an endogenous retrovirus spread primarily as part of the host germ line. While up to 10% of mammalian genomes are composed of such endogenous retroviruses (ERVs), KoRV is the only known example of a retrovirus in the process of making this transition. Thus, it presents a singular opportunity to study the host-pathogen interactions involved during retroviral invasion of a vertebrate germ line.

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The koala retrovirus (KoRV) is in transition between occurring as an exogenous retrovirus spread by infection and becoming an endogenous retrovirus spread primarily as part of the host germ line. While up to 10% of mammalian genomes are composed of such endogenous retroviruses (ERVs), KoRV is the only known example of a retrovirus in the process of making this transition. Thus, it presents a singular opportunity to study the host-pathogen interactions involved during retroviral invasion of a vertebrate germ line.

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Available abstract

The koala retrovirus (KoRV) is in transition between occurring as an exogenous retrovirus spread by infection and becoming an endogenous retrovirus spread primarily as part of the host germ line. While up to 10% of mammalian genomes are composed of such endogenous retroviruses (ERVs), KoRV is the only known example of a retrovirus in the process of making this transition. Thus, it presents a singular opportunity to study the host-pathogen interactions involved during retroviral invasion of a vertebrate germ line.

Key concepts: Endogenous retrovirus, Retrovirus, Biology, Genome, Virology, Germline, Vertebrate, Genetics

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