ScholarLens Back to search
1971•Experimental Biology and MedicineRequires access

Granulocyte Colony Stimulating Factor III. Effect of Alkylating Agent Induced Granulocytopenia

RK Shadduck, Naveen Nunna

Open publisher page 15 citations

Abstract

At intervals following a single injection of cyclophosphamide, groups of rats were tested for the presence of an in vitro granulocyte colony stimulating factor (CSF). Increased serum CSF activity was demonstrated on days 5 through 7 after injection, corresponding to a phase of marked peripheral granulocytopenia. The CSF returned to base line levels as peripheral blood granulocytes returned to normal. Increased elaboration of CSF in conjunction with granulocytopenia is in accord with a possible role of this material as a regulator of granulopoiesis.

About this research paper

What this paper is about

At intervals following a single injection of cyclophosphamide, groups of rats were tested for the presence of an in vitro granulocyte colony stimulating factor (CSF). Increased serum CSF activity was demonstrated on days 5 through 7 after injection, corresponding to a phase of marked peripheral granulocytopenia. The CSF returned to base line levels as peripheral blood granulocytes returned to normal. Increased elaboration of CSF in conjunction with granulocytopenia is in accord with a possible role of this material as a regulator of granulopoiesis.

Why it matters

OpenAlex reports 15 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

At intervals following a single injection of cyclophosphamide, groups of rats were tested for the presence of an in vitro granulocyte colony stimulating factor (CSF). Increased serum CSF activity was demonstrated on days 5 through 7 after injection, corresponding to a phase of marked peripheral granulocytopenia. The CSF returned to base line levels as peripheral blood granulocytes returned to normal. Increased elaboration of CSF in conjunction with granulocytopenia is in accord with a possible role of this material as a regulator of granulopoiesis.

Key concepts: Granulopoiesis, Granulocyte, Granulocyte colony-stimulating factor, Cyclophosphamide, Internal medicine, Peripheral blood, Endocrinology, In vitro

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Granulocyte Colony Stimulating Factor III. Effect of Alkylating Agent Induced Granulocytopenia — Research Paper | ScholarLens