Stabilisation, Analysis and Toxicokinetics of the Four Stereoisomers of the Nerve Agent Pinacolyl Methylphosphonofluoridate (Soman) in Rats

Evidence has been accumulating in our laboratories over the last few years for a far greater in vivo persistence of the nerve agent soman than previously assumed. Such persistence may be relevant for the post-acute treatment of soman poisoning since the intact soman lingering in reversible storage sites may cause a relapse into the acute phase in poisoning and lengthen the period of recovery.