1991•Practica Oto-Rhino-LaryngologicaOpen access
Tissue transfer concentration of cefminox in tonsil.
Taisuke Kobayashi, Ryuichi Aibara, Kiyofumi Gyo
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Abstract
Tissue transfer concentration of cefminox (CMNX) in the tonsil was measured in 10 adults and 8 children after tonsillectomy. One gram of CMNX was injected intravenously before tonsillectomy, and its concentrations in the tonsil and in the serum were measured after tonsil had been removed.1. In adults, mean CMNX concentration in the tonsil was 15.8μg/mg 40 to 120 minutes after administration. Tonsillar concentration was 33.1% of serum concentration.2. In children, mean CMNX concentration in the tonsil was 20.9μg/mg 25 to 100 minutes after sdministration. Tonsillar concentration was 17.4% of serum concentration.3. The half-life of CMNX in the serum was 115 minutes in adults and 83 minutes in children.CMNX is effective against a variety of bacteria. The present study proved that the administration of one gram of CMNX was sufficient to treat tonsillitis and peritonsillar abscess, since its concentration in the tonsil was above the MIC80 of most bacterial.
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