ScholarLens Back to search
1986•EnshoOpen access

Prostaglandin E2 production by macrophages, monocytes and polymorphonuclear leukocytes in rheumatoid arthritis.

Yuichiro Kondo, Morihiro Ohara, Reiji Kasukawa, Norimichi Nakahata, Hironori Nakanishi, Jun Matsumoto

Open full text 1 citations

Abstract

Macrophages in synovial fluid of patients with rheumatoid arthritis (RASF-Mφ) released prostaglandin E2 (PGE2) when they were stimulated by lipopolysaccharide (LPS), aggregated-IgG (Agg-IgG) and opsonized-Zymosan (Zymosan) . Monocytes in peripheral blood of patients with rheumatoid arthritis (RA-Mo) and normal subjects (healthy-Mo) similarly released PGE2 when they were stimulated by LPS, Agg-IgG and Zymosan. Healthy-Mo released more amount of PGE2 than RA-Mo. The reduced PGE2 release of RA-Mo might be due to the effect of nonsteroidal antiinflammatory drugs taken by RA patients. Polymorphonuclear leukocytes (PMN), in synovial fluid and peripheral blood of patients with rheumatoid arthritis along with PMN of normal subjects, released little PGE2.

Open-access reader

About this research paper

What this paper is about

Macrophages in synovial fluid of patients with rheumatoid arthritis (RASF-Mφ) released prostaglandin E2 (PGE2) when they were stimulated by lipopolysaccharide (LPS), aggregated-IgG (Agg-IgG) and opsonized-Zymosan (Zymosan) . Monocytes in peripheral blood of patients with rheumatoid arthritis (RA-Mo) and normal subjects (healthy-Mo) similarly released PGE2 when they were stimulated by LPS, Agg-IgG and Zymosan. Healthy-Mo released more amount of PGE2 than RA-Mo. The reduced PGE2 release of RA-Mo might be due to the effect of nonsteroidal antiinflammatory drugs taken by RA patients. Polymorphonuclear leukocytes (PMN), in synovial fluid and peripheral blood of patients with rheumatoid arthritis along with PMN of normal subjects, released little PGE2.

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Macrophages in synovial fluid of patients with rheumatoid arthritis (RASF-Mφ) released prostaglandin E2 (PGE2) when they were stimulated by lipopolysaccharide (LPS), aggregated-IgG (Agg-IgG) and opsonized-Zymosan (Zymosan) . Monocytes in peripheral blood of patients with rheumatoid arthritis (RA-Mo) and normal subjects (healthy-Mo) similarly released PGE2 when they were stimulated by LPS, Agg-IgG and Zymosan. Healthy-Mo released more amount of PGE2 than RA-Mo. The reduced PGE2 release of RA-Mo might be due to the effect of nonsteroidal antiinflammatory drugs taken by RA patients. Polymorphonuclear leukocytes (PMN), in synovial fluid and peripheral blood of patients with rheumatoid arthritis along with PMN of normal subjects, released little PGE2.

Key concepts: Zymosan, Rheumatoid arthritis, Prostaglandin E2, Lipopolysaccharide, Synovial fluid, Immunology, Medicine, Phagocytosis

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Prostaglandin E2 production by macrophages, monocytes and polymorphonuclear leukocytes in rheumatoid arthritis. — Research Paper | ScholarLens