1998•Seibutsu ButsuriOpen access

Regulation mechanism for initiation of chromosomal DNA replication in Escherichia coli.

Tohru Mizushima

Abstract

Re-initiation of DNA replication from a newly replicated origin has to be suppressed so that DNA replication couples with cell division. In this review, I show our original model for the suppression, DNA replication-dependent inactivation of initiator protein for DNA replication. I also describe recent studies suggesting that membrane acidic phospholipids are involved in the regulation of initiation of DNA replication in cells.

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Available abstract

Key concepts: Eukaryotic DNA replication, Control of chromosome duplication, Origin recognition complex, DNA replication, Replication factor C, Pre-replication complex, Biology, DNA replication factor CDT1