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Proliferation Activity of Stromal Stem Cells (CFU-f) from Hemopoietic Organs of Pre- and Postnatal Mice

Sigrid R. M. Versele, Rosette L. Van Den Heuvel, Greet Schoeters, O. L. J. Vanderborght

Abstract

Stromal stem cells (CFU-f assay) from hemopoietic organs of fetuses, in contrast to adult animals, exhibit a high proliferation activity. This implies that these CFU-f are radiosensitive and potential target cells after radioactive contamination of fetuses. Furthermore, the percentage of CFU-f in DNA synthesis is correlated with the hemopoietic activity in liver, spleen, and bone marrow. As hemopoiesis starts, high numbers of CFU-f are in S phase. In fetal liver, spleen, and bone marrow, values of 70, 43, and 58%, respectively, are reached. As hemopoietic activity decreases in liver and stabilizes in spleen and bone marrow, mitotic activity of these stromal stem cells becomes undetectable.

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Key concepts: Haematopoiesis, Spleen, Stromal cell, Bone marrow, Stem cell, Biology, Fetus, Mitosis