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2015•Journal of Nutrition & Food SciencesRequires access

A Comparative Study of the Impact of Dietary Calcium Sources on Serum Calcium and Bone Reformation Using an Ovariectomized Sprague-Dawley Rat Model

Bomi Framroze, Sunil Godase

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Abstract

Osteoporosis is a multifactorial skeletal disease that is characterized by compromised bone strength predisposing a person to an increased risk of fracture. This ovariectomized (OVX) Sprague-Dawley rat model study measured the changes in serum calcium, as well as femur dimensions and mineral density, when consuming calcium carbonate, calcium gluconate and salmon bone calcium. Our results show that salmon bone calcium and to a lesser extent calcium gluconate showed a statistically significant increase in femur dimension and mineral density while calcium carbonate showed no impact on either bone parameter. Our results also show that none of the three calcium sources affected serum calcium levels after 8 weeks of treatment.

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What this paper is about

Osteoporosis is a multifactorial skeletal disease that is characterized by compromised bone strength predisposing a person to an increased risk of fracture. This ovariectomized (OVX) Sprague-Dawley rat model study measured the changes in serum calcium, as well as femur dimensions and mineral density, when consuming calcium carbonate, calcium gluconate and salmon bone calcium. Our results show that salmon bone calcium and to a lesser extent calcium gluconate showed a statistically significant increase in femur dimension and mineral density while calcium carbonate showed no impact on either bone parameter. Our results also show that none of the three calcium sources affected serum calcium levels after 8 weeks of treatment.

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OpenAlex reports 4 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Osteoporosis is a multifactorial skeletal disease that is characterized by compromised bone strength predisposing a person to an increased risk of fracture. This ovariectomized (OVX) Sprague-Dawley rat model study measured the changes in serum calcium, as well as femur dimensions and mineral density, when consuming calcium carbonate, calcium gluconate and salmon bone calcium. Our results show that salmon bone calcium and to a lesser extent calcium gluconate showed a statistically significant increase in femur dimension and mineral density while calcium carbonate showed no impact on either bone parameter. Our results also show that none of the three calcium sources affected serum calcium levels after 8 weeks of treatment.

Key concepts: Ovariectomized rat, Calcium, Internal medicine, Endocrinology, Chemistry, Medicine, Pharmacology, Estrogen

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