The effect of modified neurolept analgesia (droperidol-pentazocine) on dopamine metabolism in rat.

The effect of modified neurolept analgesia method (used droperidol-pentazocine) on dopamine metabolism in rat was studied by measuring the quantity of DA, DOPAC and HVA in each dopamine neuron system using High Performance Liquid Chromatography.Appearance of catalepsy and the analgesic effect was also studied in rat.As a result, dopamine metabolism was accelerated by droperidol, but not changed by pentazocine. The acceleration effect of dopmine metabolism on the combined group, which was admininstered droperidol and pentazicine, was similar to the droperidol group.Catalepsy did not appear in the pentazocine group, but appeared in the droperidol group and combined group.Analgesic effect did not appear in the droperidol group, but appeared in the pentazocine group and combined group.Moreover, in comparing the combined group with pentazocine group, the combined group has a greater analgesic effect than the pentazocine group. Thus, the acceleration effect of dopamine metabolism is dependent on droperidol.The acceleration effect on dopamine metabolism and appearance of catalepsy by droperidol were not influenced by pentazocine, but analgesic effect of pentazocine was reinforced by adding droneridol.