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Inactivation of Gastrin and Pentagastrin by Tissue Slices

J. C. W. Evans, David D. Reeder, Jill C. Thompson

Open publisher page 8 citations

Abstract

We have studied the capacity of several mammalian tissues to inactivate synthetic human gastrin I and its synthetic analog, pentagastrin. Slices of each tissue studied were incubated with either gastrin or pentagastrin and the degree of inactivation was determined by both radioimmunoassay and bioassay. The results demonstrate that there is an in vitro potential for the inactivation of gastrin in all the tissues tested. There was a close correlation between the results obtained with radioimmunoassay and those obtained with bioassay.

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What this paper is about

We have studied the capacity of several mammalian tissues to inactivate synthetic human gastrin I and its synthetic analog, pentagastrin. Slices of each tissue studied were incubated with either gastrin or pentagastrin and the degree of inactivation was determined by both radioimmunoassay and bioassay. The results demonstrate that there is an in vitro potential for the inactivation of gastrin in all the tissues tested. There was a close correlation between the results obtained with radioimmunoassay and those obtained with bioassay.

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OpenAlex reports 8 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

We have studied the capacity of several mammalian tissues to inactivate synthetic human gastrin I and its synthetic analog, pentagastrin. Slices of each tissue studied were incubated with either gastrin or pentagastrin and the degree of inactivation was determined by both radioimmunoassay and bioassay. The results demonstrate that there is an in vitro potential for the inactivation of gastrin in all the tissues tested. There was a close correlation between the results obtained with radioimmunoassay and those obtained with bioassay.

Key concepts: Pentagastrin, Gastrin, Radioimmunoassay, Bioassay, Internal medicine, Endocrinology, In vitro, Chemistry

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