1997•JSM MycotoxinsOpen access

Effect of deoxynivalenol on humoral and cellular immune-responses to salmonella infection

Yoshiko Sugita‐Konishi, Yukiko Hara‐Kudo, Fumiko Kasuga, Masako Yamamoto, Susumu Kumagai

Abstract

Our previous work indicated that sequential exposure to a low concentration of deoxynivalenol (DON) increased the susceptibility of mice to salmonella via oral infection. In this study, the effect of DON on humoral and cellular immune defense against salmonella infection in the same conditions as the previous study was investigated. DON reduced the production of specific antibodies against salmonella and the delayed type (footpad) hypersensitivity (DTH) reaction to formalin-killed salmonella extract. These results demonstrate that the immunosuppresive effects of DON are involved in an increased susceptibility to salmonella infection.

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Key concepts: Salmonella, Immune system, Salmonella infection, Microbiology, Antibody, Humoral immunity, Immunology, Biology