The Relationship between Intra-individual Variations in the Pharmacokinetics and C-reactive Protein in Inpatients Receiving Aminoglycoside Therapy

To evaluate the correlation between the intra-individual variations in the pharmacokinetics of aminoglycoside (arbekacin and amikacin) and C-reactive protein (CRP), the serum concentrations of aminoglycoside and the CRP levels were monitored in 10 inpatients receiving arbekacin or amikacin therapy. The pharmacokinetic parameters of aminoglycoside were estimated using a one-compartment model.A significant difference was observed between the distribution volume at higher CRP levels and lower levels in inpatients receiving aminoglycoside (Vd, 0.442±0.134 vs 0.368±0.164 L/kg, P< 0.05), However, no significant relationship existed between the CRP levels and Vd of aminoglycoside, There was a significant difference in the half-life (t1/2) of seruim aminoglycoside between higher CRP levels and lower levels in inpatients receiving aminoglycoside (3.90±1.97 vs 4.46±2.02 hours, P< 0. 01).In the future, further examinations of serum aminoglycoside concentration monitoring are called for to check the intra-individual variations in the pharmacokinetics for aminoglycoside, when the CRP levels change in inpatients receiving aminoglycoside therapy.