CLINICAL EVALUATION OF THE EFFECT OF INJECTION OF INTRAOPERATIVE ANTIBIOTICS ON PREVENTION OF POSTOPERATIVE INFECTION

To prevent postoperative infection, intraoperative antibiotics therapy and washing of the operative wound is performing at the department. This paper discribes the evaluation of the prophylactic effect in 180 surgical cases not involving those with dirty procedures treated from January 1989 to January 1991. Of the 180 cases 84 were given antibiotics (antibiotics group) and 96 were not done (control group), and postoperative occurrence of wound infection and peritoneal infection were evaluated. Excepting cases complicated by anastomotic breakdown, postoperative wound infection was observed in 3 patients (3.6%) in the antibiotics group and in 5 (6.2%) in the control group; postoperative intraperitoneal infection was found in 7 (8.3%) in the antibiotics group and in 10 (11.1%) in the control group. Both wound and intraperitoneal infections were less frequent in the antibiotics group than in the control group, although the differences were not statistically significant. Postoperative bacterial positive ratio was not directly concerning to the ratio of infection growth.In conclusion, intraoperative antibiotics injection therapy is usefull for post operative infection. But its effects have some limitations. Other foctors such as patients themselves and the causative bacteria may play more important role in one onset of postoperative infection.