1990•Japanese Journal of Smooth Muscle ResearchOpen access
Effects of cisapride on gastric emptying.
Toshifumi Kanaizumi, Taisuke MATSUI, Hidenori TATSUMI, Hirofumi Ishikawa, Ryousuke Shimizu, Suiru PAKU, Hiroshige Nakano
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Abstract
To evaluate the effects of cisapride on gastric emptying, gastric emptying was measured in six healthy volunteers using radioisotopic techniques which were established three areas of interest, i.e. the whole stomach, the proximal stomach and the antrum. Following results were obtained. 1. At the half emptying times, cisapride induced a more rapid gastric emptying than did placebo in 5 of 6 volunteers. 2. By analyzing gastric emptying curves obtained from three areas of interest, it was suggested that cisapride enhanced the transfer of gastric contents from the proximal stomach to the antrum together with the antral emptying, so that gastric emptying was accelerated.
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