1997•PubMedOpen access

[Determination of DNA content in salivary gland tumors].

Milly Yáñez, Iván Roa, Miguel Villaseca, Patricia Fuentealba

Abstract

BACKGROUND: DNA content determination is a useful tool in the characterization of different malignant tumors. AIM: To measure DNA content in cells of salivary gland tumors as adjunct to histological diagnosis, correlating morphologic and biological features of these tumors. MATERIAL AND METHODS: From the archives of the Pathology service of a general hospital, 21 salivary gland tumors, 15 pleomorphic adenomas, 3 mucoepidermoid carcinomas and 3 cystic adenoid carcinomas were selected. DNA content was determined in the histological samples using a flow cytometric DNA analysis. RESULTS: All pleomorphic adenomas had a normal or diploid DNA content. Fifty percent of malignant tumors had an aneuploid DNA content (1 mucoepidermoid carcinoma and 2 cystic adenoid carcinomas). CONCLUSIONS: DNA determination may help in the histological diagnosis of salivary gland tumors. The presence of aneuploidy suggests malignity.

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Key concepts: Salivary gland, Mucoepidermoid carcinoma, Pathology, Adenoid cystic carcinoma, Pleomorphic adenoma, Adenoid, DNA, Carcinoma