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A Prodrome for Multiple Myeloma

Michael E. Williams

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) occurs in 3% to 4% of older individuals (age, >60) and is identified by the presence of serum monoclonal immunoglobulin without overt multiple myeloma (MM), other plasma cell dyscrasia, or lymphoproliferative disorder. About 1.0% to 1.5% of MGUS cases per year progress to MM or related diseases. However, we do not know whether MGUS precedes MM in all cases. To find out, two groups of investigators prospectively collected …

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Key concepts: Monoclonal gammopathy of undetermined significance, Plasma cell dyscrasia, Prodrome, Medicine, Multiple myeloma, Dyscrasia, Monoclonal gammopathy, Paraproteinemias