Bactericidal activity of ciprofloxacin alone and in combination with azlocillin in an in-vitro capillary model

An in-vitro pharmacokinetic model was used to study the bactericidal activity of ciprofloxacin, alone and in combination with azlocillin. Ciprofloxacin alone produced excellent bactericidal activity against highly susceptible strains of Escherichia coli and Klebsiella pneumoniae. Against a strain of Pseudomonas aeruginosa, ciprofloxacin in clinically achievable dosing schedules produced a rapid bactericidal effect, but bacterial regrowth occurred. Azlocillin in combination with ciprofloxacin produced a rapid bacterial kill and regrowth was prevented. Further consideration of the clinical role of this combination is warranted.