1986•Indian Journal of PharmacologyRequires access

Bioavailability and pharmacokinetics of three digoxin preparations in healthy adults

Gul Shahnaz, V. Amla, Raina Rk

Abstract

1. Single dose concentration time profile was determined by EMIT in six healthy volunteers following administration of 0.5 mg digoxin in tablet form from three different manufacturers. 2. Bioavailability as measured by area under serum digoxin concentration time curves appeared to be higher with British Pharmaceutical Laboratories (BPL) than the other two products; Burroughs Wellcome (BW) and Tablets India Ltd. (TI).

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Key concepts: Digoxin, Bioavailability, Pharmacokinetics, Pharmacology, Serum concentration, Medicine, Chemistry, Internal medicine