Effect of losartan on the ultrastructural morphology of blood cells in patients with diabetes mellitus and hypertension

Ultrastructural changes of blood cells in with patients with hypertension of 1-2-degree, in patients with diabetes mellitus type 2 at compensation and subcompensation phase as well as in patientswith diabetes mellitus and hypertensionduring correction of blood pressure with losartan was defined. It is shown that in patients with hypertension of 1-2-degree relative content of activated platelets does not differ from the normal level. In patients with diabetes mellitus type 2 at compensation or subcompensation phase increase of degree of platelet activation, regardless of presence (150.9%) or absence of hypertension (141.5%) is observed. Conducted antihyper­tensive therapy does not affect the spontaneous activation of platelets within 1 year. In patients with hypertension potential aggregation of platelets is the most sensitive element of platelet hemostasis damage, which can be normalized beginning with 6-th month of losartan treatment. In patients with diabetes mellitus type 2 with hypertension elevation of platelet aggregation is the most significant (75.4%) and areliable effect of antihypertensive therapy on limitation of platelet aggregation is achieved in 9 months of treatment. The degree of platelet degranulation is not different from the norm in patients with hypertension and significantly elevated in patients with diabetes mellitus type 2 (by 81.0%), during 1-year observation a constant level of the parameter is revealed. In the group of patients with diabetes mellitus andhypertension, where the original content of degranulated platelets is sharplyincreased (by 76.2%), a significant positive dynamics in the course of treatment with losartan is observed.