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2015•Neurochemical JournalRequires access

The dynorphin/kappa-opioid system of the brain as a promising target for therapy for dependence on psychoactive substances

Ф. Ш. Шагиахметов, T.V. Proskuryakova, I.Yu. Shamakina

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Abstract

Dynorphin is an endogenous opioid peptide that has the largest affinity to kappa-opioid receptors (KORs). Administration of dynorphin and KOR agonists has aversive, prodysphoric, and depressogenic effects on humans and animals. We believe that the dynorphin/kappa-opioid system may play the role of negative feedback that regulates the activity of monoaminergic neurotransmission in the brain; thus, KORs may be considered as a promising target for the development of drugs for the prevention of a relapse of PAS dependence.

About this research paper

What this paper is about

Dynorphin is an endogenous opioid peptide that has the largest affinity to kappa-opioid receptors (KORs). Administration of dynorphin and KOR agonists has aversive, prodysphoric, and depressogenic effects on humans and animals. We believe that the dynorphin/kappa-opioid system may play the role of negative feedback that regulates the activity of monoaminergic neurotransmission in the brain; thus, KORs may be considered as a promising target for the development of drugs for the prevention of a relapse of PAS dependence.

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Available abstract

Dynorphin is an endogenous opioid peptide that has the largest affinity to kappa-opioid receptors (KORs). Administration of dynorphin and KOR agonists has aversive, prodysphoric, and depressogenic effects on humans and animals. We believe that the dynorphin/kappa-opioid system may play the role of negative feedback that regulates the activity of monoaminergic neurotransmission in the brain; thus, KORs may be considered as a promising target for the development of drugs for the prevention of a relapse of PAS dependence.

Key concepts: Dynorphin, κ-opioid receptor, Monoaminergic, Dynorphin A, Opioid, Opioid peptide, Kappa, Endogeny

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