Preliminary investigation on the MDR-TB and XDR-TB of MTB clinical isolates from Xinjiang area.

Objective:By drug-susceptibility testing of clinical isolated Mycobacterium tuberculosis (M.TB) to four first-line and seven second-line anti-TB drugs,to know the situation of multidrug resistant tuberculosis(MDR-TB)and extensively drug-resistant tuberculosis (XDR-TB) in part areas of Xinjiang.Methods:The sputum samples of patients with TB were collected from Nov.1th,2008 to Oct.31th,2009 to conduct isolated culture and phenotypical classification.The anti-tuberculosis drugs were performed to detect the drugresistance with the method of the proportion method.Results:102 isolates were obtained,88 strains (86.3%)were identified to M.TB complex isolates.Among 88 M.TB complex isolates,the general resistance rate to at least one drug were 22.7%.6 isolates (6.8%) were found to be MDR-TB,2 isolates (33.3%) were found to be pre-XDR,and no XDR-TB was found in this study.Conclusion:Kashi Prefecture,Xinjiang,a higher rate of drug-resistant TB patients in TB treatment should be given full attention,in particular,should strengthen the importance of Pre-XDR,so to develop into XDR-TB.