2007•Southern African Journal of Anaesthesia and AnalgesiaOpen access

Postoperative nausea and vomiting : what about substance P antagonism? (or is it just another empty promise? : guest editorial

E. Oosthuizen

Abstract

Nausea and vomiting are now considered to be ultimately mediated by a central common pathway. Neurokinin 1 (substance P) is the synaptic mediator at this level. Aprepitant is a substance P antagonist at neurokinin 1 receptors and is now available in North America for the prevention of postoperative nausea and vomiting. A basic summary is provided on the physiological and pharmacological basis of this agent.

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Available abstract

Key concepts: Aprepitant, Vomiting, Nausea, Substance P, Medicine, Antagonist, Anesthesia, NK1 receptor antagonist