Synthesis of some Newer Pyrimidinone Derivatives as Potential Analgesics and Anti-Inflammatory Agents

A number of substituted chalcones (1a-1o) were synthesized by the reaction of substituted benzaldehyde and substituted acetophenone in presence of ethanolic sodium hydroxide solution. On further treating these substituted chalcones (1a-1o ) with urea in alkaline medium, yielded a series of 4,6 disubstituted pyrimidine-2-one derivatives (2a-2o). The structures of the newly synthesized compounds have been established on the basis of IR, 1 H-NMR, MS (ESI) data and elemental analysis. All the compounds were screened for their analgesic activity by Acetic acid induced writhing method and anti-inflammatory activity by Carrageenan induced hind paw oedema assay.