SYNTHESIS, SPECTRAL STUDIES AND ANTIMICROBIAL SCREENING OF SOME TRANSITION METAL COMPLEXES WITH SUBSTITUTED ACETOPHENONE THIOSEMICARBAZONE

ABSTRACT: Complexs of Fe, Cu and Zn have been prepared by reacting metal chloride\\sulphate with p-hydroxyacetophenone thiosemicarbazone, p-fluoroacetophenone thiosemicarbazone, p-bromoacetophenone thiosemicarbazone as ligands and their complexes were screened for their IR, NMR, and antifungal and antibacterial studies.. Acetophenone thiosemicarbazone ligands were prepared by the reaction of substituted acetophenone with thiosemicarbazone in the presence of hot ethanol. All the transition-ligands 1:2 complexes have been isolated in the solid state, are stable in air, and characterized on the basis of their elemental and spectral data. They were found to be active against influenza, protozoa, small pox, and certain kinds of tumor. Their metal complexes were used, in various biological systems, polymers, dyes, anti-inflammatory, analgesic and anti-oxidative action. The Schiff bases and their metal complexes were used in various biological activities such as